Information Sciences in Imaging 2013 Seminar Series: ISIS/Canary February Seminar


How imaging mass spectrometry paves the way to the spatially-resolved systems biology


Imaging mass spectrometry (imaging MS) has emerged in the last decade as a label-free, spatially-resolved, and multi-purpose bioanalytical technique for direct analysis of biological samples from animal tissue, plant tissue, biofilms, and polymer films. Recent developments include single cell imaging, sub-ppm mass accuracy, molecular quantification, detection of low-abundant molecules, and characterization of isomeric molecules. 

After the decade of collective efforts, imaging MS became an analytical technique of choice for establishing spatial systems biology at the levels of organ and organism. This challenging goal requires new algorithms for construction, analysis, interpretation, and visualization of hyperspectral imaging data, as well as integration of imaging data with molecular networks, and data from other imaging modalities, such as microscopy and MRI. 

In this talk, I will present these algorithms and how they can be used for solving such biomedical problems as biomarker discovery, drug imaging, and analysis of microbial interactions. At the end of my talk, I will highlight recent advances in the visualization of 3D MALDI imaging mass spectrometry data.